Research & Initiatives
Developing a Childhood Asthma Risk Passive Digital Marker: To develop and determine the usability, acceptability, feasibility, and preliminary efficacy of a childhood asthma Passive Digital Marker (PDM) for early disease detection. Here, a PDM refers to a ML algorithm that can be used to retrieve and synthesize pre-existing ‘Passively’ collected mother/child dyad prognostic data (i.e., medical history) at ages 0-3 years in ‘Digital’ EHR to provide an objective and quantifiable ‘Marker’ of a child’s asthma risk and phenotype at ages 6-10 years.
Developing a passive digital marker (PDM) for childhood asthma treatment response prediction: Develop, validate, and evaluate the predictive performance of a childhood asthma Passive Digital Marker for treatment response prediction (PDM-TR), that is, a machine learning algorithm that can retrieve and synthesize pre-existing ‘passively’ collected mother-child dyad risk/prognostic data in ‘digital’ electronic health record (EHR) to provide an objective and quantifiable ‘marker’ of future treatment response.
I-CARE 2 RCT: Mobile Telehealth to Reduce Alzheimer’s-related Symptoms for Caregivers and Patients: This randomized clinical trial tests how telehealth technology can positively affect informal caregivers and patients living with Alzheimer’s disease and related dementias. The project will gather data over time to measure the impact of our evidence-based Brain CareNotes mobile telehealth app on informal caregiver burden and patients’ behavioral and psychological symptoms of dementia, in a diverse Indiana-wide sample.
The Agile Nudge University Program: The overall goal of the proposed Agile Nudge University will be accomplished by first, establishing the Agile Nudge University virtual curriculum; second, recruiting, training, mentoring, and supporting graduate students, postdoctoral fellows, and early, mid-career, and senior faculty who are interested in ADRD research; and third, engineering a national collaborative and psychologically safe social network of highly engaged and diverse ADRD scientists through wrap-around online social platform.
The Esthetician’s Perspectives and Practices Study: The objective of this proposed project is to build on the Sexual Health and Estheticians (SHE) Study, focusing on estheticians who serve men, and determine the acceptability of/feasibility for a salon-based intervention.
Pharmacotherapy in conjunction with lifestyle counseling for management of weight regain after bariatric surgery (PROJECT-BARI): A 12-month, double-blind, RCT to examine the efficacy of anti-obese pharmacotherapy (topiramate and phentermine) on reversing weight regain in subjects with bariatric surgery.
Gonadal hormones as mediators of sex and gender influences in asthma: Sex and gender disparities in the severity and frequency of asthma exacerbations have been extensively reported, yet the biological and hormonal basis of these differences have not been elucidated. This application will investigate the mechanisms by which estrogen triggers inflammation in the male and female asthmatic lung to determine the molecular basis of hormonal triggers of asthma exacerbations in cis and transgender women and lead to the future development of better personalized therapeutic options for lung disease.
Blood-Biomarkers and Risk Factors of Acute Brain Injury associated with Neurodisability in Ugandan Children [BRAIN-Child]: Neurocognitive impairment (NCI) is a common complication following traumatic brain injury (TBI) in all age ranges, worldwide. There is no current research that identifies blood-biomarkers of brain injury or risk factors including glucose abnormalities, cellular injury, and endothelial dysfunction in children at risk of NCI after TBI in resource limited low- and middle-income countries. This project will fill that gap by exploring whether a set of biomarkers can be used in pediatric TBI to determine if these biomarkers can predict NCI at 6-months, and embed this work within a framework to expand interdisciplinary research capacity in Uganda.
Improving aphasia outcomes through transcranial direct current stimulation (tDCS)-Mediated attention management: This is an innovative RCT study intervention that will test the hypothesis that participants with aphasia who receive behavioral attention training paired with active anodal tDCS to dorsolateral prefrontal cortex (DLPFC) will demonstrate significantly greater improvement on a behavioral measure of attention than participants who receive behavioral attention training paired with sham tDCS.
Digital Detection of Dementia (D3) Studies: This project evaluates the predictive performance of two low-cost approaches for the early detection of Alzheimer’s Disease and related dementias using patient-reported outcome data, and to evaluate the practical utility and effect of the Passive Digital Marker and the Quick Dementia Rating Scale methods in improving the annual rate of new documented ADRD diagnosis in primary care practices.