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Translational Informatics, Biostatistics and Epidemiology Lab

What do we do?

The Translational Informatics, Biostatistics and Epidemiology laboratory (TIBE Labs) led by Dr. Arthur Owora applies novel biostatistical and machine learning methodologies to different (structured and unstructured) and multiple data sources (active and passive) to generate analytics and insights regarding disease etiology, risk, and prognosis. Through collaboration with clinicians, the TIBE laboratory aims to translate such insights to inform effective clinical decision-making at point-of-care including more proactive and personalized care, for improved patient-centered outcomes in real-world healthcare settings.

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Research Funding

Developing a Childhood Asthma Risk Passive Digital Marker

K01HL163462 | Owora (PI) | 12/01/2022-11/30/2026​

 

To develop and determine the usability, acceptability, feasibility, and preliminary efficacy of a childhood asthma Passive Digital Marker (PDM) for early disease detection. Here, a PDM refers to a ML algorithm that can be used to retrieve and synthesize pre-existing ‘Passively’ collected mother/child dyad prognostic data (i.e., medical history) at ages 0-3 years in ‘Digital’ EHR to provide an objective and quantifiable ‘Marker’ of a child’s asthma risk and phenotype at ages 6-10 years.
 

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Recent Publications

(* student mentees/advisees)

Rodriguez MJ, Kercher VM, Jordan EJ, Savoy A, Hill JR, Werner N, Owora A, Castelluccio P, Boustani MA, Holden RJ. Technology caregiver intervention for Alzheimer's disease (I-CARE): Feasibility and preliminary efficacy of Brain CareNotes. J Am Geriatr Soc. 2023 Dec;71(12):3836-3847. doi: 10.1111/jgs.18591. Epub 2023 Sep 14. PubMed PMID: 37706540; NIHMSID:NIHMS1929174.

Rogerson C, Owora A, Tu W, Mendonca E. The influence of social and environmental determinants of health on hospitalizations for pediatric asthma. J Asthma. 2023 Nov 27;:1-10. doi: 10.1080/02770903.2023.2288323. [Epub ahead of print] PubMed PMID: 38010826.

Rogerson C, Owora A, He T, Carroll A, Schleyer T, AbuSultaneh S, Tu W, Mendonca E. High flow nasal cannula use is associated with increased hospital length of stay for pediatric asthma. Pediatr Pulmonol. 2023 Nov;58(11):3046-3053. doi: 10.1002/ppul.26617. Epub 2023 Aug 2. PubMed PMID: 37530483.

Yamamoto N, Ejima K, Mestre LM, Owora AH, Inoue M, Tsugane S, Sawada N. Body mass index trajectories and mortality risk in Japan using a population-based prospective cohort study: the Japan Public Health Center-based Prospective Study. Int J Epidemiol. 2023 Oct 25;. doi: 10.1093/ije/dyad145. [Epub ahead of print] PubMed PMID: 37878816.

Vinjimoor S, Vieira C, Rogerson C, Owora A, Mendonca EA. Social risk factors for pediatric asthma exacerbations: A systematic review. medRxiv. 2023 Sep 20;. doi: 10.1101/2023.09.19.23295732. PubMed PMID: 37790526; PubMed Central PMCID: PMC10543039.

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